Introduction
Imagine sinking your teeth into a slice of hot, cheesy, and pepperoni-packed pizza. The combination of gooey cheese, zesty tomato sauce, and savory pepperoni is enough to make anyone’s taste buds dance with delight. But what if you could take that classic pizza experience and transform it into a comforting casserole? That’s where the Ultimate Cheesy Pepperoni Pizza Casserole comes in.
This recipe takes all the flavors you love from a traditional pepperoni pizza and layers them into a delicious and easy-to-make casserole. It’s the perfect dish for those nights when you’re craving pizza but don’t want to go through the hassle of making or ordering a whole pie. Plus, it’s a great option for feeding a crowd or meal prepping for the week ahead.
Why You’ll Love This Recipe
There are so many reasons to love this Ultimate Cheesy Pepperoni Pizza Casserole. First and foremost, it’s incredibly delicious. The combination of melted cheese, zesty tomato sauce, and crispy pepperoni is a winning flavor combination that will have everyone coming back for seconds.
Not only is this casserole bursting with flavor, but it’s also incredibly easy to make. With just a handful of simple ingredients, you can have this dish on the table in no time. It’s perfect for those busy weeknights when you need a quick and satisfying meal.
Another great thing about this recipe is its versatility. You can easily customize it to suit your preferences. Add extra veggies like bell peppers and onions for a more colorful and nutritious dish. Or swap out the pepperoni for your favorite pizza toppings, such as sausage or mushrooms. The possibilities are endless!
Ingredients
Here are the ingredients you’ll need to make the Ultimate Cheesy Pepperoni Pizza Casserole:
- 1 pound penne pasta
- 1 tablespoon olive oil
- 1 small onion, diced
- 2 cloves garlic, minced
- 1 pound ground beef
- 1 can (28 ounces) crushed tomatoes
- 2 teaspoons dried oregano
- 1 teaspoon dried basil
- 1/2 teaspoon salt
- 1/4 teaspoon black pepper
- 2 cups shredded mozzarella cheese
- 1/2 cup grated Parmesan cheese
- 1 cup sliced pepperoni
Step-by-Step Instructions
- Preheat your oven to 375°F (190°C). Grease a 9×13-inch baking dish with cooking spray or butter.
- Cook the penne pasta according to the package instructions until al dente. Drain and set aside.
- In a large skillet, heat the olive oil over medium heat. Add the diced onion and minced garlic, and sauté until the onion is translucent and fragrant, about 5 minutes.
- Add the ground beef to the skillet and cook until browned. Drain any excess grease.
- Stir in the crushed tomatoes, dried oregano, dried basil, salt, and black pepper. Simmer for 10 minutes to allow the flavors to meld together.
- In the prepared baking dish, layer half of the cooked penne pasta. Top with half of the meat sauce, followed by half of the mozzarella and Parmesan cheeses. Repeat the layers with the remaining ingredients.
- Arrange the sliced pepperoni on top of the casserole.
- Bake for 25-30 minutes, or until the cheese is melted and bubbly.
- Remove from the oven and let it cool for a few minutes. Serve hot and enjoy!
Expert Tips for Success
Here are a few tips to help you make the best Ultimate Cheesy Pepperoni Pizza Casserole:
– For extra flavor, you can add some Italian seasoning or crushed red pepper flakes to the meat sauce.
– Feel free to use your favorite type of pasta instead of penne. Rotini, rigatoni, or even macaroni will work just as well.
– If you want a crispier topping, broil the casserole for a couple of minutes at the end of the baking time.
Variations and Substitutions
This recipe is incredibly versatile, and there are plenty of ways to customize it to suit your taste preferences or dietary needs. Here are a few ideas:
– Vegetarian Option: Omit the ground beef and replace it with diced bell peppers, onions, and mushrooms for a flavorful vegetarian version.
– Gluten-Free Option: Use gluten-free pasta and ensure that all other ingredients, such as the pepperoni and cheeses, are also gluten-free.
– Healthier Option: Substitute whole wheat pasta for a fiber boost, and use turkey pepperoni or even sliced turkey breast instead of regular pepperoni.
Serving Suggestions
The Ultimate Cheesy Pepperoni Pizza Casserole is a complete meal on its own, but you can enhance the dining experience by serving it with a few complementary side dishes. Here are some ideas:
– Garlic Bread: Whip up a batch of garlic bread to serve alongside the casserole. The warm, garlicky bread is perfect for sopping up any extra sauce.
– Salad: A crisp green salad is a refreshing accompaniment to the rich and cheesy casserole. Toss together your favorite greens, cherry tomatoes, and a simple vinaigrette.
– Beverage: Pair this hearty dish with a cold glass of your favorite soda, a refreshing iced tea, or even a chilled beer for the adults.
FAQs
Q: Can I make this casserole ahead of time?
A: Absolutely! You can assemble the casserole up to a day in advance and refrigerate it until you’re ready to bake. Just be sure to increase the baking time slightly since the dish will be cold from the refrigerator.
Q: Can I freeze the leftovers?
A: Yes, this casserole freezes well. Allow it to cool completely, then transfer individual portions or the entire casserole to airtight containers or freezer bags. It can be stored in the freezer for up to 3 months. To reheat, thaw in the refrigerator overnight and bake in a preheated oven until heated through.
Q: Can I use a different type of cheese?
A: Absolutely! While mozzarella and Parmesan cheese are traditional choices for pizza, feel free to experiment with other cheeses like cheddar, provolone, or a blend of your favorites.
Final Thoughts
The Ultimate Cheesy Pepperoni Pizza Casserole is a crowd-pleasing dish that brings all the flavors of a classic pepperoni pizza to a convenient and comforting casserole format. It’s easy to make, incredibly delicious, and endlessly customizable. Whether you’re feeding a hungry family or hosting a casual dinner party, this recipe is sure to be a hit. So go ahead, gather your ingredients, and get ready to indulge in a slice of pizza heaven!

Ultimate Cheesy Pepperoni Pizza Casserole
Transform the classic flavors of pepperoni pizza into a comforting casserole with layers of cheesy goodness. This easy-to-make dish is perfect for a quick and satisfying meal that can be customized to suit your preferences.
Ingredients
- 1 pound penne pasta
- 1 tablespoon olive oil
- 1 small onion, diced
- 2 cloves garlic, minced
- 1 pound ground beef
- 1 can (28 ounces) crushed tomatoes
- 2 teaspoons dried oregano
- 1 teaspoon dried basil
- 1/2 teaspoon salt
- 1/4 teaspoon black pepper
- 2 cups shredded mozzarella cheese
- 1/2 cup grated Parmesan cheese
- 1 cup sliced pepperoni
Directions
-
Preheat your oven to 375°F (190°C). Grease a 9×13-inch baking dish with cooking spray or butter.
-
Cook the penne pasta according to the package instructions until al dente. Drain and set aside.
-
In a large skillet, heat the olive oil over medium heat. Add the diced onion and minced garlic, and sauté until the onion is translucent and fragrant, about 5 minutes.
-
Add the ground beef to the skillet and cook until browned. Drain any excess grease.
-
Stir in the crushed tomatoes, dried oregano, dried basil, salt, and black pepper. Simmer for 10 minutes to allow the flavors to meld together.
-
In the prepared baking dish, layer half of the cooked penne pasta. Top with half of the meat sauce, followed by half of the mozzarella and Parmesan cheeses. Repeat the layers with the remaining ingredients.
-
Arrange the sliced pepperoni on top of the casserole.
-
Bake for 25-30 minutes, or until the cheese is melted and bubbly.
-
Remove from the oven and let it cool for a few minutes. Serve hot and enjoy!